An inter-departmental research team has conducted an analytic real-world cohort study on the association of clozapine, a highly efficacious antipsychotic drug, with the incidence of blood cancer. Their findings show that the risk of blood cancer associated with the use of clozapine is very low, with an average increase of less than six cases per 10,000 persons using clozapine for one year. Therefore, the clinical significance of such a risk is plausibly low. While previous preliminary Western studies have shown a potentially significant increase in risk, this study suggests that with stringent blood monitoring measures before and during clozapine use in Hong Kong and around the world, it may not be necessary to further restrict the use of clozapine or issue special warnings by the Department of Health or local drug regulatory authorities, thus facilitating early and effective treatment of mental illness.
Read more …Research on clozapine safety: Big-data evidence on rare blood cancer cases
Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.
Read more …Zebrafish protein unlocks dormant genes for heart repair
Recognizing that news coverage may have influence in forming attitudes and in driving action, a team of psychology researchers examined whether reframing this gender gap in terms of 'men's overrepresentation' -- rather than as 'women's underrepresentation' -- would have an impact on perceptions of the issue and on motivations to address it. Its findings showed that framing the gap as 'men's overrepresentation' -- as opposed to 'women's underrepresentation' -- in political leadership elicited more anger at the disparity among women and increased perceptions that the gap is unjust. Moreover, the results showed that anger at the disparity leads women to take action to address it.
Read more …Too many men or too few women? New study finds how the gender gap is framed affects perceptions of...