The surprising role of gut infection in Alzheimer's disease

Researchers have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in a subset of people. It is believed most humans are exposed to this virus -- called cytomegalovirus or HCMV -- during the first few decades of life. According to the new research, in some people, the virus may linger in an active state in the gut, where it may travel to the brain via the vagus nerve -- a critical information highway that connects the gut and brain. Once there, the virus can change the immune system and contribute to other changes associated with Alzheimer's disease. This virus may be a target for antiviral treatments.

Researchers have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in a subset of people. It is believed most humans are exposed to this virus -- called cytomegalovirus or HCMV -- during the first few decades of life. According to the new research, in some people, the virus may linger in an active state in the gut, where it may travel to the brain via the vagus nerve -- a critical information highway that connects the gut and brain. Once there, the virus can change the immune system and contribute to other changes associated with Alzheimer's disease. This virus may be a target for antiviral treatments.

Read more https://www.sciencedaily.com/releases/2024/12/241219152410.htm