New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of developmental gene expression, revealing a key mechanism that has so far eluded experimental scrutiny. These findings provide insight into the intricate cellular processes that control development, how cell types are specified from stem cells, and how cell identity is established. Deciphering these mechanisms is not only key to understand fundamental biology but will also ultimately pave the way for the development of regenerative medicine approaches.
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