A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team identified a monoclonal antibody called KG2032 that reacts with a certain variant of the HLA-DRB1 molecule. KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar results. Clinical trials are currently being planned.
Read more …Driving the CAR to fight acute myeloid leukemia

A new, error-corrected method for detecting cancer from blood samples is much more sensitive and accurate than prior methods and may be useful for monitoring disease status in patients following treatment, according to a new study. The method, based on whole-genome sequencing of DNA, also represents an important step toward the goal of routine blood test-based screening for early cancer detection.
Read more …New strategy may enable cancer monitoring from blood tests alone

Diagram of a crossed-out eye and the words 'Sensitive Content'

While pornography has been present throughout human history in various forms, such as ancient erotic art to more modernized motion pictures, research shows an increase in use[1] over recent decades given the rise of technology and accessibility.

Pornography, meaning any media intended to depict or describe sexual content[2] to heighten sexual arousal or pleasure, can serve many purposes[3]. Users may seek sexual pleasure, find it...

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