New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease. The researchers believe this class of drugs, widely used to treat a number of cardiovascular diseases, hold promise as a future treatment for DM1.
Read more …Calcium channel blockers key to reversing myotonic dystrophy muscle weakness
Farmers in sub-Saharan Africa need to diversify away from growing maize and switch to crops that are resilient to climate change and supply enough key micronutrients for the population, according to a major research study. Maize is a staple crop across the region -- where it is grown and consumed in vast quantities.
Read more …'Nutritional quality must be at the heart of climate smart agriculture' -- researchers
Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal and chemical stability as well as ability to inhibit specific enzymes or target proteins through three-dimensional binding. They also hold promise for swift diagnoses of colon cancer and other challenging diseases by targeting elusive biomarkers. Despite their utility, these aptamers are susceptible to easy degradation by multiple enzymes, presenting a significant challenge.
Read more …Aptamers: lifesavers; ion shields: aptamer guardians