Friday, May 09, 2025
Friday, May 09, 2025

Researchers have developed a human in vitro model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung. Using a previously developed microfluidic human Lung Alveolus Chip lined by human lung alveolar epithelial cells interfaced with lung capillary cells to recreate the alveolar-capillary interface in vitro, the researchers recapitulated many of the hallmarks of RILI, including radiation-induced DNA damage in lung tissue, cell-specific changes in gene expression, inflammation, and injury to both the lung epithelial cells and blood vessel-lining endothelial cells. By also evaluating the potential of two drugs to suppress the effects of acute RILI, the researchers demonstrated their model's capabilities as an advanced, human-relevant, preclinical, drug discovery platform.
Read more …Human Lung Chip leveraged to faithfully model radiation-induced lung injury

Glioblastoma is the most common type of brain tumor that affects adults and, unfortunately, still remains incurable. In a new study, researchers have demonstrated that a specific mitochondrial protein plays an important role in glioblastoma, and can therefore be used as a potential target to reduce tumors.
Read more …Mitochondrial protein plays key role in glioblastoma and therapeutic resistance

More Articles …

  1. Adults with ADHD are at increased risk for developing dementia
  2. Brain connectivity is disrupted in schizophrenia
  3. Boosting weak immune system: Scientists find an unusual weapon against virus
  4. Depression, anxiety common among college students
  5. Smarter CT scans may approach the level of MRI
  6. New study reveals similarities between chimpanzee and human language development
Page 1392 of 1521