Although sedentary behavior may be an evolutionarily selected trait, it is still important to try to be physically active, says a new study. Researchers have shown for the first time that genetic predisposition to sedentary behavior is associated with a higher risk of developing the most common cardiovascular diseases. A high genetic predisposition to sedentary behavior can increase the risk of cardiovascular diseases by up to 20%.

Organoids are made to model human organs and are promising for research and therapy, but there are limitations in their growth and function. A recent study found that placenta-derived IL1 under hypoxic conditions, can greatly increase growth of human stem cell-derived liver organoids. By promoting liver progenitor cell expansion through a specific signaling pathway, this method offers a promising route to improve organoid models and regenerative medicine.

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